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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10227315 B1

PDFFull Text
Date of Patent:
Mar. 12, 2019

Filed:

May. 18, 2017

Mitochondrial uncouplers for treatment of metabolic diseases and cancer

Applicant:

Rutgers, the State University of New Jersey, New Brunswick, NJ (US);

Inventors:

Shengkan Jin, Belle Mead, NJ (US);

David J. Augeri, Princeton, NJ (US);

Bin Cao, Highland Park, NJ (US);

Hanlin Tao, Branchburg, NJ (US);

Assignee:

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US);

Attorney:

Pepper Hamilton LLP

Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07D 277/82 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); A61K 31/167 (2006.01); A61K 31/277 (2006.01); A61K 31/428 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/536 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01); C07C 235/64 (2006.01); C07C 255/60 (2006.01); C07D 241/20 (2006.01); C07D 295/205 (2006.01); C07F 9/6541 (2006.01);
U.S. Cl.
CPC ...
C07D 277/82 (2013.01); A61K 31/167 (2013.01); A61K 31/277 (2013.01); A61K 31/428 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/536 (2013.01); A61K 31/5375 (2013.01); A61K 31/5377 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07C 235/64 (2013.01); C07C 255/60 (2013.01); C07D 241/20 (2013.01); C07D 295/205 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07F 9/6541 (2013.01);
Abstract

The present disclosure relates to benzamide compounds, prodrugs of the compounds, pharmaceutical compositions containing the compounds and/or the prodrugs and methods of using the compounds, prodrugs and pharmaceutical compositions in the treatment of diseases related to lipid metabolism including diabetes, Non-Alcholic Fatty Liver Disease (NAFLD), Non-Alcholic Steathohepatitis (NASH), diseases caused by abnormal cell proliferation including cancer, psoriasis, and infectious diseases.

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