The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 12, 2019

Filed:

Feb. 07, 2013
Applicants:

The Regents of the University of California, Oakland, CA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

Michael A. Fischbach, San Francisco, CA (US);

Jeffrey A. Bluestone, San Francisco, CA (US);

Cristina Penaranda, Boston, MA (US);

Laura Brown, Bloomington, IN (US);

Jon Clardy, Jamaica Plain, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/12 (2015.01); A61K 35/26 (2015.01); C07H 15/04 (2006.01); C07H 15/06 (2006.01); C12P 13/02 (2006.01); C12P 19/44 (2006.01); C07C 235/08 (2006.01); C07F 9/141 (2006.01);
U.S. Cl.
CPC ...
C07C 235/08 (2013.01); A61K 35/26 (2013.01); C07F 9/1411 (2013.01); C07H 15/04 (2013.01); C07H 15/06 (2013.01); C12P 13/02 (2013.01); C12P 19/44 (2013.01); A61K 2035/122 (2013.01);
Abstract

Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.


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