The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2019
Filed:
Dec. 18, 2014
Applicant:
The University of Nottingham, Nottingham, GB;
Inventors:
Assignee:
The University of Nottingham, , GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C07H 21/04 (2006.01); C07K 1/00 (2006.01); A61K 47/64 (2017.01); C07K 14/475 (2006.01);
U.S. Cl.
CPC ...
A61K 47/645 (2017.08); C07K 14/475 (2013.01); C07K 2319/10 (2013.01); C07K 2319/20 (2013.01); C07K 2319/33 (2013.01);
Abstract
This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.