The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2019
Filed:
Dec. 10, 2013
Mersana Therapeutics, Inc., Cambridge, MA (US);
Aleksandr V. Yurkovetskiy, Littleton, MA (US);
Mao Yin, Needham, MA (US);
Timothy B. Lowinger, Carlisle, MA (US);
Cheri A. Stevenson, Haverhill, MA (US);
Patrick R. Conlon, Wakefield, MA (US);
Mersana Therapeutics, Inc., Cambridge, MA (US);
Abstract
An auristatin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently an auristatin compound having a molecular weight ≤5 kDa. Land Lare distinct linkers connecting the auristatin compound and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-auristatin compound-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.