The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2019
Filed:
May. 26, 2015
Applicant:
Relaxera Pharmazeutische Gesellschaft Mbh & Co. KG, Bensheim, DE;
Inventor:
Thomas B. Dschietzig, Berlin, DE;
Assignee:
Relaxera Pharmazeutische Gesellschaft mbH & Co. KG, Bensheim, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/22 (2006.01); A61P 9/04 (2006.01); A61K 9/00 (2006.01); A61K 9/113 (2006.01); C07K 14/64 (2006.01);
U.S. Cl.
CPC ...
A61K 38/2221 (2013.01); A61K 9/006 (2013.01); A61K 9/0019 (2013.01); A61K 9/113 (2013.01); A61P 9/04 (2018.01); C07K 14/64 (2013.01);
Abstract
A pharmaceutical composition for treatment of persons afflicted of heart failure with preserved ejection fraction (HFPEF), diastolic heart failure (DHF) or diastolic dysfunction (DF), the composition comprising a therapeutically effective amount of a compound capable of specific binding to the relaxin receptor (RXFP1) present on fibroblasts, fibromyoblasts, endothelial cells, endocardial cells, and cardiomyocytes in the cardiac muscle to increase the heart's stroke volume at lower end-diastolic pressure.