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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10226459 B1

PDFFull Text
Date of Patent:
Mar. 12, 2019

Filed:

Sep. 29, 2017

Aza spiro alkane derivatives as inhibitors of metalloproteases

Applicants:

Incyte Corporation, Wilmington, DE (US);

Incyte Holdings Corporation, Wilmington, DE (US);

Inventors:

Wenqing Yao, Chadds Ford, PA (US);

Jincong Zhuo, Garnet Valley, PA (US);

Meizhong Xu, Hockessin, DE (US);

Fenglei Zhang, Berwyn, PA (US);

Brian W. Metcalf, Moraga, CA (US);

Assignees:

Incyte Holdings Corporation, Wilmington, DE (US);

Incyte Corporation, Wilmington, DE (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Alexander R Pagano

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/40 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/4985 (2006.01); A61K 31/55 (2006.01); A61K 31/551 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 221/20 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); A61K 31/495 (2006.01);
U.S. Cl.
CPC ...
A61K 31/496 (2013.01); A61K 31/40 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/495 (2013.01); A61K 31/4985 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); C07D 221/20 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01);
Abstract

The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.

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