The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2019
Filed:
Jul. 31, 2015
Applicant:
Intron Biotechnology Co., Ltd, Seongnam-si, KR;
Inventors:
Yeo Joon Yoon, Seoul, KR;
Ho Jeong Kwon, Seoul, KR;
Yeon Hee Ban, Seoul, KR;
Shinde Pramodb, Seoul, KR;
Assignee:
INTRON BIOTECHNOLOGY CO., LTD, Seongnam-si, KR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/436 (2006.01); A61K 31/4025 (2006.01); C12P 17/16 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4025 (2013.01); A61K 31/436 (2013.01); C12P 17/16 (2013.01);
Abstract
The present invention relates to an FK506 derivative which has reduced immunosuppressive activity but maintains nerve regeneration activity, a preparing method thereof, and a pharmaceutical composition comprising the same for preventing or treating nervous system diseases. A composition comprising 9-deoxo-prolyl-FK506, 31-O-demethyl-FK506, or 9-deoxo-31-O-demethyl-FK506 can promote nerve regeneration and has reduced immunosuppressive activity, thereby reducing side effects in the treatment of nervous system diseases.