The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2019
Filed:
Jun. 29, 2017
Adaptive Biotechnologies Corp., Seattle, WA (US);
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Harlan S. Robins, Seattle, WA (US);
Julie Rubinstein, Seattle, WA (US);
Ryan Emerson, Seattle, WA (US);
Jianda Yuan, New York, NY (US);
ADAPTIVE BIOTECHNOLOGIES CORP., Seattle, WA (US);
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
Abstract
Disclosed are methods for determining the immunological status of the adaptive immune system of a subject by identifying and quantifying rearranged DNA (and/or subsequently transcribed RNA) sequences encoding T cell receptor (TCR) and/or immunoglobulin (IG) polypeptides, in a lymphoid DNA-containing sample from the subject TCR and/or IG sequence diversity and sequence distribution permit immunocompetence and immune repertoire assessment and reflect the degree of T cell or B cell clonality and clerical expansion in the sample. Methods for stratifying patient populations on the basis of immunocompetence including likelihood of responding to immunotherapy are also described.