The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2019
Filed:
Jul. 21, 2016
Applicants:
Novo Nordisk A/s, Bagsvaerd, DK;
Takara Bio Europe Ab, Gothenburg, SE;
Inventors:
Jenny Ekberg, Malmoe, SE;
Mattias Hansson, Malmoe, SE;
Ulrik Doehn, Veskoe, DK;
Katja Hess, Heidelberg, DE;
Nina Funa, Lund, SE;
Assignees:
Novo Nordisk A/S, Bagsværd, DK;
TAKARA BIO EUROPE AB, Gothenburg, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0676 (2013.01); C12N 5/0678 (2013.01); C12N 2501/115 (2013.01); C12N 2501/117 (2013.01); C12N 2501/119 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/385 (2013.01); C12N 2501/41 (2013.01); C12N 2501/415 (2013.01); C12N 2501/60 (2013.01); C12N 2501/727 (2013.01); C12N 2501/999 (2013.01); C12N 2503/02 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01);
Abstract
A method of producing pancreatic cells or pancreatic cell precursors expressing at least 5% PDX1/NKX6.1 double positive, comprising exposing definitive endoderm cells to an effective amount of one or more small molecules, to differentiate the human definitive endoderm cells into the pancreatic cells or pancreatic cell precursors. The present invention also relates to pancreatic endoderm cells produced by said methods and uses of said pancreatic endoderm cells.