The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2019
Filed:
Dec. 21, 2015
Applicant:
The Rockefeller University, New York, NY (US);
Inventors:
Sohail Tavazoie, New York, NY (US);
Nils Halberg, Brooklyn, NY (US);
Masoud Tavazoie, New York, NY (US);
Assignee:
The Rockefeller University, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/40 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 45/06 (2006.01); A61K 31/436 (2006.01); A61K 31/138 (2006.01); A61K 31/337 (2006.01); A61K 31/404 (2006.01); A61K 31/44 (2006.01); A61K 31/4535 (2006.01); A61K 31/475 (2006.01); A61K 31/513 (2006.01); A61K 31/655 (2006.01); A61K 31/675 (2006.01); A61P 35/00 (2006.01); C07K 16/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A61K 31/138 (2013.01); A61K 31/337 (2013.01); A61K 31/404 (2013.01); A61K 31/436 (2013.01); A61K 31/44 (2013.01); A61K 31/4535 (2013.01); A61K 31/475 (2013.01); A61K 31/513 (2013.01); A61K 31/655 (2013.01); A61K 31/675 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 16/00 (2013.01); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/75 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.