The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2019
Filed:
Jun. 06, 2016
Zhejiang Tianyu Pharmaceutical Co., Ltd., Taizhou, Zhejiang, CN;
Guorong Zhu, Zhejiang, CN;
Yongjun Tu, Zhejiang, CN;
Wenlong Xie, Zhejiang, CN;
Zhen Wang, Zhejiang, CN;
Shaojun Xu, Zhejiang, CN;
ZHEJIANG TIANYU PHARMACEUTICAL CO., LTD., Taizhou, Zhejiang, CN;
Abstract
The present invention discloses a method for preparing an anti-heart-failure medicine LCZ696. The preparing method comprises the following step (formula (I)): in an organic solvent, a Sacubitril dicyclohexylamine salt reacts with valsartan under the effect of a sodium hydroxide aqueous solution, and the anti-heart-failure medicine LCZ696 is obtained. The preparing method of the present invention is simple in process and omits the procedures of ion exchange from a sodium salt to a calcium salt and hydrochloric acid dissociation in an existing production process, residues of calcium ions are avoided, and the production efficiency is effectively improved.