The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2019
Filed:
Aug. 07, 2015
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Ravi K. Amaravadi, Media, PA (US);
Jeffrey Winkler, Wynnewood, PA (US);
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/46 (2006.01); A61K 31/4706 (2006.01); A61K 31/4709 (2006.01); C07D 401/12 (2006.01); A61K 31/436 (2006.01); A61K 31/4375 (2006.01); A61K 31/4545 (2006.01); A61K 31/4745 (2006.01); A61K 31/4995 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 31/704 (2006.01); A61K 31/7056 (2006.01);
U.S. Cl.
CPC ...
C07D 215/46 (2013.01); A61K 31/436 (2013.01); A61K 31/4375 (2013.01); A61K 31/4545 (2013.01); A61K 31/4706 (2013.01); A61K 31/4709 (2013.01); A61K 31/4745 (2013.01); A61K 31/4995 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/704 (2013.01); A61K 31/7056 (2013.01); C07D 401/12 (2013.01); Y02A 50/411 (2018.01);
Abstract
The invention provides novel asymmetric and symmetric bisaminoquinolmes and related compounds, methods of treatment and syntheses. The novel compounds exhibit effective anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.