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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10220385 B1

PDFFull Text
Date of Patent:
Mar. 05, 2019

Filed:

Nov. 01, 2016

Micro-tube particles for microfluidic assays and methods of manufacture

Applicant:

Proteinsimple, San Jose, CA (US);

Inventors:

Martin A. Putnam, Cheshire, CT (US);

Jeffrey T. Branciforte, Hartford, CT (US);

Charles O. Stanwood, Durham, CT (US);

Jane M. Tu, Cheshire, CT (US);

Assignee:

CyVek, Inc., Wallingford, CT (US);

Attorney:

McCormick, Paulding & Huber LLP

Primary Examiner:

Brian J Sines

Int. Cl.
CPC ...
B28B 11/06 (2006.01); G01N 15/06 (2006.01); G01N 33/00 (2006.01); G01N 33/48 (2006.01); B01L 3/00 (2006.01); G01N 33/543 (2006.01); G01N 21/05 (2006.01); G01N 21/64 (2006.01); G01N 21/03 (2006.01); G01N 35/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502707 (2013.01); B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); G01N 21/05 (2013.01); G01N 21/645 (2013.01); G01N 33/54366 (2013.01); G01N 33/54386 (2013.01); B01L 2200/0689 (2013.01); B01L 2200/12 (2013.01); B01L 2200/16 (2013.01); B01L 2300/087 (2013.01); B01L 2300/0832 (2013.01); B01L 2300/0838 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/0896 (2013.01); B01L 2300/12 (2013.01); B01L 2300/123 (2013.01); B01L 2300/168 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0638 (2013.01); B01L 2400/0655 (2013.01); B01L 2400/086 (2013.01); G01N 2021/0346 (2013.01); G01N 2021/058 (2013.01); G01N 2035/00158 (2013.01); Y10T 29/494 (2015.01);
Abstract

A method for preparing a plurality of micro-length tubular flow elements for use in a fluid assay, each element having interior and exterior surfaces and having at least one axially-extending flow passage through its interior, includes aggressively agitating the flow elements in a solution of assay capture agent to impart disrupting shear forces on the exterior surface of the elements, the shear forces causing the axially-extending external surfaces of the flow elements to be free of assay capture agent, while at least a portion of the interior surface of the flow elements not experiencing such disruptive shear forces and carrying deposits of the assay capture agent.

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