The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2019
Filed:
Apr. 03, 2014
The General Hospital Corporation, Boston, MA (US);
Francesco Sabbatino, Boston, MA (US);
Yangyang Wang, Malden, MA (US);
Xinhui Wang, Boston, MA (US);
Steven Isakoff, Brookline, MA (US);
Cristina Ferrone, Boston, MA (US);
Joe Schwab, Boston, MA (US);
Soldano Ferrone, Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Methods for treating cancer using a combination of an inhibitor of the sonic hedgehog signaling pathway (e.g., LDE225) with radiation and a tumor antigen-specific monoclonal antibody (e.g., heat shock protein (HSP) glucose regulated protein of 94000 daltons (Grp94)-specific mAb W9, or chondroitin sulfate proteoglycan 4 (CSPG4)-targeted mAbs), or with a BRAF inhibitor, e.g., in BRAF inhibitor resistant cancers.