The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 26, 2019

Filed:

Oct. 16, 2014
Applicant:

National Institute of Advanced Industrial Science and Technology, Tokyo, JP;

Inventors:

Sung Bae Kim, Tsukuba, JP;

Hiroshi Izumi, Tsukuba, JP;

Hiroaki Tao, Tsukuba, JP;

Masaki Torimura, Tsukuba, JP;

Akihiro Wakisaka, Tsukuba, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/66 (2006.01); C07D 241/38 (2006.01); C12N 9/02 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/66 (2013.01); C07D 241/38 (2013.01); C07D 487/04 (2013.01); C12N 9/0069 (2013.01); C12Y 113/12 (2013.01); C12Y 113/12007 (2013.01);
Abstract

The invention relates to a bioluminescent substrate suitably usable in a series of artificial luciferases (ALuc), and the invention provides a wavelength-shifted spectrum with a selective high intensity luminescence and high luminescence stability obtained by the use of the substrate together with ALuc. The luminescent substrate for ALuc obtained by the invention can be included together with a suitable luminescence solution in a luminescence kit. The bioluminescent substrate for ALuc of the invention can exhibit unprecedented excellent luminescence specificity and functionality in the conventional bioluminescence probe, two-hybrid assay, bioluminescent capsule, and reporter gene assay.


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