The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2019
Filed:
Apr. 04, 2017
Methods for differentiation of human pluripotent stem cells to brain microvascular endothelial cells
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Tongcheng Qian, Madison, WI (US);
Eric V. Shusta, Madison, WI (US);
Sean P. Palecek, Verona, WI (US);
Assignee:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/079 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0618 (2013.01); C12N 2500/38 (2013.01); C12N 2500/90 (2013.01); C12N 2501/115 (2013.01); C12N 2501/415 (2013.01); C12N 2506/45 (2013.01);
Abstract
Methods for generating functional brain microvascular endothelial cells (BMECs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for generating functional BMECs under chemically defined culture conditions are provided. BMECs obtained according to the methods provided herein are suitable for in vitro blood brain barrier (BBB) formation.