The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2019
Filed:
Jan. 27, 2017
Genzyme Corporation, Cambridge, MA (US);
Clark Pan, Sutton, MA (US);
Qun Zhou, Ashland, MA (US);
James Stefano, Hopkinton, MA (US);
Pradeep Dhal, Westford, MA (US);
Bo Chen, Boston, MA (US);
Diego Gianolio, Somerville, MA (US);
Robert Miller, East Bridgewater, MA (US);
Huawei Qiu, Westborough, MA (US);
GENZYME CORPORATION, Cambridge, MA (US);
Abstract
The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.