The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 26, 2019

Filed:

Feb. 08, 2017
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

John Y. L. Chung, Edison, NJ (US);

Amude Kassim, Fairless Hills, PA (US);

John Limanto, Jersey City, NJ (US);

Michael Shevlin, Middlesex, NJ (US);

Peter E. Maligres, Fanwood, NJ (US);

Daniel A. DiRocco, Lebanon, PA (US);

James F. Dropinski, Freehold, NJ (US);

Rose Mathew, Ringoes, NJ (US);

Yi Ning Ji Chen, Clark, NJ (US);

Edward C. Sherer, Hillsborough, NJ (US);

Mikhail Reibarkh, Cranford, NJ (US);

Artis Klapars, Edison, NJ (US);

Alan Hyde, Jersey City, NJ (US);

Susan L. Zultanski, Brooklyn, NY (US);

Aaron Moment, New York, NY (US);

Bryon Simmons, Hamilton, NJ (US);

Tyler A. Davis, Westfield, NJ (US);

Timothy James Wright, Clark, NJ (US);

Ralph Calabria, East Brunswick, NJ (US);

Louis charles Campeau, Morris Plains, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/00 (2006.01); C07H 19/048 (2006.01); C07H 19/10 (2006.01); C07H 19/06 (2006.01); C07H 19/24 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07H 19/10 (2013.01); C07D 487/04 (2013.01); C07H 19/06 (2013.01); C07H 19/24 (2013.01);
Abstract

The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).


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