The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2019
Filed:
Oct. 21, 2015
Bristol-myers Squibb Company, Princeton, NJ (US);
Rajeev S. Bhide, Bangalore, IN;
Douglas G. Batt, Wilmington, DE (US);
Robert J. Cherney, Newton, PA (US);
Lyndon A. M. Cornelius, Jackson, NJ (US);
Qingjie Liu, Newton, PA (US);
David Marcoux, Pennington, NJ (US);
James Neels, Holland, PA (US);
Michael A. Poss, Lawrenceville, NJ (US);
Zheming Ruan, Dayton, NJ (US);
Qing Shi, Princeton, NJ (US);
Anurag S. Srivastava, Belle Mead, NJ (US);
Lan-ying Qin, Plainsboro, NJ (US);
Joseph A. Tino, Lawrenceville, NJ (US);
Scott Hunter Watterson, Pennington, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Qis: (i) Cl, Br, I, —CN, —CH, or —CF; (ii) a 5-membered heteroaryl selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, and thiadiazolyl; (iii) a 6?membered heteroaryl selected from pyridinyl, pyridazinyl, and pyrimidinyl; or (iv) a bicyclic heteroaryl selected from indolyl, pyrrolopyridinyl, pyrazolopyridinyl and benzo[d]oxazolyl; wherein each of said 5-membered, 6-membered, and bicyclic heteroaryl is substituted with zero to 1 Rand zero to 1 R; and R, R, R, R, R, R, R, and Rare defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.