The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 26, 2019

Filed:

Feb. 24, 2016
Applicants:

Max-delbrück-centrum Für Molekulare Medizin, Berlin, DE;

Forschungsverbund Berlin E.v., Berlin, DE;

Inventors:

Michael Bader, Berlin, DE;

Edgar Specker, Berlin, DE;

Susann Matthes, Berlin, DE;

Anja Schütz, Berlin, DE;

Keven Mallow, Berlin, DE;

Maik Grohmann, Eltville, DE;

Marc Nazaré, Berlin, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 473/06 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); A61K 31/522 (2006.01); A61P 3/04 (2006.01); A61P 11/06 (2006.01); A61P 19/10 (2006.01); A61P 25/18 (2006.01); A61P 25/24 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 473/06 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation comprising the xanthine derivative. The novel xanthine compounds are capable of inhibiting tryptophan hydroxylases (TPH) involved in the biosynthesis of serotonin and are effective in influencing the serotonin level in the body.


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