The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 26, 2019

Filed:

Jun. 21, 2017
Applicants:

Curis, Inc., Lexington, MA (US);

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Xiong Cai, Bedford, MA (US);

Changgeng Qian, Wayland, MA (US);

Haixiao Zhai, Bedford, MA (US);

Assignees:

Curis, Inc., Lexington, MA (US);

Genentech, Inc., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 401/12 (2006.01); C07D 239/26 (2006.01); C07D 213/16 (2006.01); C07D 235/18 (2006.01); C07D 403/12 (2006.01); C07D 213/56 (2006.01); C07D 239/42 (2006.01); C07D 213/82 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); C07D 213/16 (2013.01); C07D 213/56 (2013.01); C07D 213/82 (2013.01); C07D 235/18 (2013.01); C07D 239/42 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01);
Abstract

The present invention provides compounds which antagonize hedgehog signaling and inhibit HDAC activity. The compounds can be used in methods of treating proliferative diseases and disorders such as cancer.


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