The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2019
Filed:
Feb. 04, 2014
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Marikki Laiho, Towson, MD (US);
Karita Peltonen, Vantaa, FI;
Assignee:
THE JOHNS HOPKINS UNIVERSITY, Baltimore, unknown;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/435 (2006.01); A61K 31/47 (2006.01); A61K 31/4706 (2006.01); C07D 215/54 (2006.01); C07D 215/16 (2006.01); C07D 215/46 (2006.01); C07D 215/42 (2006.01); C07D 215/48 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
C07D 215/54 (2013.01); A61K 31/435 (2013.01); A61K 31/47 (2013.01); A61K 31/4706 (2013.01); A61K 31/519 (2013.01); C07D 215/16 (2013.01); C07D 215/42 (2013.01); C07D 215/46 (2013.01); C07D 215/48 (2013.01);
Abstract
The invention presents methods of identifying small molecule compounds that are activators of tumor suppressor protein p53 pathway, and its associated family members p63 and p73, function. The invention is further drawn to methods of killing tumor cells and treating cancers or other conditions requiring activation of the p53 family member pathways and DNA damage response pathways with the small molecules.