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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10213407 B1

PDFFull Text
Date of Patent:
Feb. 26, 2019

Filed:

Dec. 01, 2016

Compounds and methods for inhibiting production of trimethylamine

Applicants:

The Procter & Gamble Company, Cincinnati, OH (US);

The Cleveland Clinic Foundation, Cleveland, OH (US);

Inventors:

Jose Carlos Garcia-Garcia, CIncinnati, OH (US);

Stanley Leon Hazen, Pepper Pike, OH (US);

John August Wos, Mason, OH (US);

Assignees:

THE PROCTER & GAMBLE COMPANY, Cincinnati, OH (US);

THE CLEVELAND CLINIC FOUNDATION, Cleveland, OH (US);

Attorney:

James E. Oehlenschlager

Primary Examiner:

Susan M Hanley

Int. Cl.
CPC ...
C12N 9/00 (2006.01); A61K 31/26 (2006.01); A61K 31/145 (2006.01); A61K 31/166 (2006.01); A61K 31/216 (2006.01); A61K 31/22 (2006.01); A61K 31/325 (2006.01); A61K 31/351 (2006.01); A61K 31/5375 (2006.01); A61K 31/27 (2006.01); A61K 31/4453 (2006.01); A61K 45/06 (2006.01); A61K 31/336 (2006.01); A61K 31/439 (2006.01); A61K 31/4425 (2006.01); A61K 31/452 (2006.01); C07C 331/20 (2006.01); C07D 211/46 (2006.01); C07D 213/04 (2006.01); C07D 213/30 (2006.01); C07D 213/65 (2006.01); C07D 295/13 (2006.01); C07D 303/36 (2006.01); C07D 453/02 (2006.01); A61K 31/04 (2006.01); A61K 31/095 (2006.01); A61K 31/275 (2006.01);
U.S. Cl.
CPC ...
A61K 31/26 (2013.01); A61K 31/04 (2013.01); A61K 31/095 (2013.01); A61K 31/145 (2013.01); A61K 31/166 (2013.01); A61K 31/216 (2013.01); A61K 31/22 (2013.01); A61K 31/27 (2013.01); A61K 31/275 (2013.01); A61K 31/325 (2013.01); A61K 31/336 (2013.01); A61K 31/351 (2013.01); A61K 31/439 (2013.01); A61K 31/4425 (2013.01); A61K 31/4453 (2013.01); A61K 31/452 (2013.01); A61K 31/5375 (2013.01); A61K 45/06 (2013.01); C07C 331/20 (2013.01); C07D 211/46 (2013.01); C07D 213/04 (2013.01); C07D 213/30 (2013.01); C07D 213/65 (2013.01); C07D 295/13 (2013.01); C07D 303/36 (2013.01); C07D 453/02 (2013.01);
Abstract

The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual a composition comprising a compound set forth in FORMULA (I): The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.

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