The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2019
Filed:
Mar. 20, 2015
Applicant:
Agilent Technologies, Inc., Loveland, CO (US);
Inventors:
Magdalena Anna Ostrowski, Mountain View, CA (US);
Rudolf Grimm, San Jose, CA (US);
Kevin P. Killeen, Woodside, CA (US);
Karla M. Robotti, Cupertino, CA (US);
Assignee:
AGILENT TECHNOLOGIES, INC., Santa Clara, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); G01N 33/00 (2006.01); G01N 33/68 (2006.01); F16K 99/00 (2006.01); G01N 27/447 (2006.01); G01N 30/46 (2006.01); G01N 30/60 (2006.01); G01N 30/72 (2006.01); B01D 15/08 (2006.01); G01N 1/40 (2006.01); G01N 30/08 (2006.01); H01J 49/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6842 (2013.01); B01D 15/08 (2013.01); B01L 3/502738 (2013.01); B01L 3/502753 (2013.01); F16K 99/0001 (2013.01); G01N 27/44791 (2013.01); G01N 30/465 (2013.01); G01N 30/6095 (2013.01); G01N 30/7266 (2013.01); B01L 3/502761 (2013.01); B01L 2200/10 (2013.01); B01L 2300/0627 (2013.01); B01L 2300/0874 (2013.01); B01L 2300/0887 (2013.01); B01L 2400/0406 (2013.01); B01L 2400/0421 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0644 (2013.01); G01N 1/405 (2013.01); G01N 2030/085 (2013.01); G01N 2400/00 (2013.01); H01J 49/00 (2013.01);
Abstract
Microfluidic devices and methods for analyzing glycan profiles of glycoproteins are provided. Some embodiments of the devices comprise a deglycosylation column for cleaving glycans, an optional cleaning column for removing proteins, a trapping column for enriching glycans, and a separation column for resolving glycans. The devices and methods significantly improve the speed and sensitivity of glycan analysis.