The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 19, 2019

Filed:

Apr. 14, 2015
Applicant:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Inventors:

Adam Zlotnick, Bloomington, IN (US);

Stella Vieweger, Louisville, KY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/04 (2006.01); A61K 39/12 (2006.01); A61K 39/17 (2006.01); C12N 7/00 (2006.01); C12Q 1/68 (2018.01); C12Q 1/70 (2006.01); C12Q 1/6818 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/703 (2013.01); C12Q 1/6818 (2013.01); C12Q 1/70 (2013.01); C12Q 2600/136 (2013.01);
Abstract

Virus capsids protect the viral genome and play roles in its delivery and intracellular transport, making them an attractive target for antiviral therapeutics. The difficulty in targeting capsid assembly is to identify molecules that interfere with the weak protein-protein interactions that drive the reaction. We have developed an in vitro assay for capsid assembly that works on a range of viruses at biologically relevant protein concentrations to facilitate screening large libraries of chemicals for lead compounds.


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