The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2019
Filed:
Oct. 27, 2010
Fredrik Frejd, Stockholm, SE;
Elin Gunneriusson, Saltsjöbaden, SE;
Nina Kronqvist, Täby, SE;
John Löfblom, Huddinge, SE;
Stefan Ståhl, Stockholm, SE;
Fredrik Frejd, Stockholm, SE;
Elin Gunneriusson, Saltsjöbaden, SE;
Nina Kronqvist, Täby, SE;
John Löfblom, Huddinge, SE;
Stefan Ståhl, Stockholm, SE;
AFFIBODY AB, Solna, SE;
Abstract
The disclosure provides a HER3 binding polypeptide, comprising a HER3 binding motif, BM, which motif consists of the amino acid sequence selected from i) EXXXA XXEIW XLPNL XXXQXXAFIXXLXD, and ii) an amino acid sequence which has at least 90% identity to the sequence defined in i), wherein the polypeptide binds to the extra-cellular domain of HER3. Also provided is a bispecific ligand having binding affinity for HER3 and for HER2, or for HER3 and for EGFR, and comprising a HER3. binding polypeptide as defined herein and a HER2 binding polypeptide or a EGFR binding polypeptide.