The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2019
Filed:
Jan. 19, 2018
Applicant:
Duquesne University of the Holy Ghost, Pittsburgh, PA (US);
Inventor:
Aleem Gangjee, Allison Park, PA (US);
Assignee:
Duquesne University of the Holy Ghost, Pittsburgh, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 239/70 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); C07D 239/70 (2013.01);
Abstract
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.