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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10208023 B1

PDFFull Text
Date of Patent:
Feb. 19, 2019

Filed:

Feb. 27, 2014

Heterocyclic inhibitors of the sodium channel

Applicant:

Mark G. Degiacomo, Boston, MA (US);

Inventors:

Hassan Pajouhesh, West Vancouver, CA;

Richard Holland, Vancouver, CA;

Lingyun Zhang, Vancouver, CA;

Hossein Pajouhesh, Coquitlam, CA;

Jason Lamontagne, Burnaby, CA;

Brendan Whelan, Vancouver, CA;

Assignee:

Other;

Attorneys:

Entralta P.C.

Jeffrey M. McQuiston

Peter D. Weinstein

Primary Examiner:

Clinton A Brooks

Int. Cl.
CPC ...
C07D 403/06 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 233/76 (2006.01); C07D 401/04 (2006.01); C07D 235/14 (2006.01); C07D 401/12 (2006.01); C07D 241/08 (2006.01); C07D 241/44 (2006.01); C07D 265/30 (2006.01); C07D 207/08 (2006.01); C07D 207/16 (2006.01); C07D 211/58 (2006.01); C07D 211/60 (2006.01); C07D 295/18 (2006.01); C07C 237/08 (2006.01); C07C 237/18 (2006.01); C07C 237/20 (2006.01); C07C 237/24 (2006.01); C07D 207/09 (2006.01); C07D 295/185 (2006.01);
U.S. Cl.
CPC ...
C07D 403/06 (2013.01); C07C 237/08 (2013.01); C07C 237/18 (2013.01); C07C 237/20 (2013.01); C07C 237/24 (2013.01); C07D 207/08 (2013.01); C07D 207/09 (2013.01); C07D 207/16 (2013.01); C07D 211/58 (2013.01); C07D 211/60 (2013.01); C07D 233/76 (2013.01); C07D 235/14 (2013.01); C07D 241/08 (2013.01); C07D 241/44 (2013.01); C07D 265/30 (2013.01); C07D 295/18 (2013.01); C07D 295/185 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01);
Abstract

The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (I)-(X) or Compounds (1)-(92) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotrophic lateral sclerosis, glaucoma, ischemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.

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