The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2019
Filed:
Dec. 16, 2016
University of Kentucky Research Foundation, Lexington, KY (US);
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Rockville, MD (US);
Sylvie Garneau-Tsodikova, Lexington, KY (US);
Oleg V. Tsodikov, Lexington, KY (US);
James E. Posey, Rockville, MD (US);
University of Kentucky Research Foundation, Lexington, KY (US);
Abstract
Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.