The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2019
Filed:
Sep. 29, 2016
Taisho Pharmaceutical Co., Ltd., Tokyo, JP;
Norikazu Otake, Tokyo, JP;
Daisuke Matsuda, Tokyo, JP;
Rie Shimono, Tokyo, JP;
Hideaki Tabuse, Tokyo, JP;
Minoru Moriya, Tokyo, JP;
Yohei Kobashi, Tokyo, JP;
Yohei Matsuda, Tokyo, JP;
Tomokazu Tamaoki, Tokyo, JP;
TAISHO PHARMACEUTICAL CO., LTD, Tokyo, JP;
Abstract
A novel process for producing optically active 2-(2-fluorobiphenyl-4-yl)propanoic acid is disclosed. This production process is characterized in that a compound of formula [1] is reacted with magnesium and so forth to prepare an organometallic reagent, which is reacted with a compound of formula [2] in the presence of a catalytic amount of a nickel compound and a catalytic amount of an optically active compound of formula [3] to obtain a compound represented by formula [4] which is subsequently converted to a compound represented by formula [5] or a pharmaceutically acceptable salt thereof.