The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2019
Filed:
May. 07, 2015
Tron Translationale Onkologie an Der Universitatsmedizin Der Johannes Gutenbe, Mainz, DE;
Biontech Rna Pharmaceuticals Gmbh, Mainz, DE;
Ugur Sahin, Mainz, DE;
Tim Beissert, Gross-Gerau, DE;
Marco Poleganov, Frankfurt, DE;
Stephanie Herz, Kasel, DE;
Lars Koste, Mainz, DE;
TRON TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSM, Mainz, DE;
BIONTECH RNA PHARMACEUTICALS GMBH, Mainz, DE;
Abstract
The present invention relates to expressing RNA in cells and, in particular, enhancing viability of cells in which RNA is to be expressed. Specifically, the present invention provides methods for expressing RNA in cells comprising the steps of preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells. Thus, preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells allows repetitive transfer of RNA into the cells.