The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2019
Filed:
Dec. 25, 2014
Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai, CN;
Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, Jiangsu, CN;
Xiangdong Qu, Shanghai, CN;
Xin Ye, Shanghai, CN;
Jijun Yuan, Shanghai, CN;
Lei Zhang, Shanghai, CN;
Kan Chen, Shanghai, CN;
Lianshan Zhang, Shanghai, CN;
Guoqing Cao, Shanghai, CN;
Zhibin Xu, Shanghai, CN;
Weikang Tao, Shanghai, CN;
Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai, CN;
Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, Jiangsu, CN;
Abstract
Provided is an IL-15 heterodimeric protein, such as an IL-15/IL-15Rα heterodimeric protein. The IL-15 heterodimeric protein contains protein (I) and protein (II). Protein (I) is recombinantly produced by combining IL-15 or a variant thereof with a first Fc variant, and protein (II) is a second Fc variant, or recombinantly produced by combining IL-15Rα or a variant thereof with a second Fc variant. The first Fc variant and the second Fc variant are preferably linked via a 'Knob-into-Hole' mode. Also provided are methods of using the IL-15 heterodimeric proteins to modulate an immune response. The provided IL-15 heterodimeric proteins have significant anti-tumor activity, better biological activity and prolonged in vivo half-life compared to the IL-15 molecule alone.