The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2019
Filed:
Nov. 05, 2015
Applicant:
Emory University, Atlanta, GA (US);
Inventors:
Young-Sup Yoon, Atlanta, GA (US);
Jaeyeaon Cho, Decatur, GA (US);
Assignee:
Emory University, Atlanta, GA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/33 (2015.01); C12N 15/113 (2010.01); A61K 38/18 (2006.01); A61K 31/375 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61K 35/33 (2013.01); A61K 31/375 (2013.01); A61K 38/1875 (2013.01); C12N 5/0657 (2013.01); C12N 15/113 (2013.01); C12N 2310/141 (2013.01); C12N 2320/31 (2013.01); C12N 2500/38 (2013.01); C12N 2501/155 (2013.01); C12N 2501/65 (2013.01); C12N 2506/1307 (2013.01);
Abstract
This disclosure relates to compositions comprising ascorbic acid and bone morphogenetic protein 4 (BMP-4) for growing cells and making tissues. In certain embodiments, this disclosure relates to methods of creating cardio-mimetic tissues (CMTs) by culturing the cells in the presence of ascorbic acid and bone morphogenetic protein 4 and optionally inserting into cells a muscle specific microRNA or related nucleobase polymer and under conditions such that a cardio-mimetic tissue is formed that is capable of spontaneously contracting.