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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10206912 B1

PDFFull Text
Date of Patent:
Feb. 19, 2019

Filed:

Dec. 19, 2016

Heteroaryl sulfonamides and ccr2/ccr9

Applicant:

Chemocentryx, Inc., Mountain View, CA (US);

Inventors:

Solomon Ungashe, Fremont, CA (US);

Zheng Wei, Union City, CA (US);

Arindrajit Basak, Mountain View, CA (US);

Trevor T. Charvat, San Jose, CA (US);

Wei Chen, Fremont, CA (US);

Jeff Jin, Fremont, CA (US);

Jimmie Moore, Redwood City, CA (US);

Yibin Zeng, San Mateo, CA (US);

Sreenivas Punna, Palo Alto, CA (US);

Daniel Dairaghi, Palo Alto, CA (US);

Derek Hansen, San Francisco, CA (US);

Andrew M. K. Pennell, San Francisco, CA (US);

John J. Wright, Redwood City, CA (US);

Antoni Krasinski, Mountain View, CA (US);

Qiang Wang, Sunnyvale, CA (US);

Assignee:

ChemoCentryx, Inc., Mountain View, CA (US);

Attorneys:

Brinks Gilson & Lione

Ryan L. Marshall

Jonathan M. Hartley

Primary Examiner:

Heidi Reese

Int. Cl.
CPC ...
C07C 311/21 (2006.01); A61K 31/444 (2006.01); C07D 213/75 (2006.01); C07D 241/22 (2006.01); C07D 401/06 (2006.01); C07D 401/10 (2006.01); C07D 407/04 (2006.01); C07D 409/12 (2006.01); C07D 413/06 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/444 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 45/06 (2013.01); C07C 311/21 (2013.01); C07D 213/75 (2013.01); C07D 241/22 (2013.01); C07D 401/06 (2013.01); C07D 401/10 (2013.01); C07D 407/04 (2013.01); C07D 409/12 (2013.01); C07D 413/06 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01);
Abstract

Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.

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