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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10206379 B1

PDFFull Text
Date of Patent:
Feb. 19, 2019

Filed:

Jan. 10, 2018

Non-human animals having a humanized signal-regulatory protein gene

Applicant:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

Andrew J. Murphy, Croton-on-Hudson, NY (US);

O. Gavin Thurston, Briarcliff Manor, NY (US);

Bindu Varghese, Hopewell Junction, NY (US);

Cagan Gurer, Chappaqua, NY (US);

Assignee:

REGENERON PHARMACEUTICALS, INC., Tarrytown, NY (US);

Attorneys:

Scully, Scott, Murphy & Presser, P.C.

Elysa Goldberg

Primary Examiner:

Anne Marie S Wehbe

Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 15/90 (2006.01); C12N 5/10 (2006.01); A61K 49/00 (2006.01); C12N 15/85 (2006.01); C12N 15/89 (2006.01); G01N 33/50 (2006.01); C12N 9/16 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A61K 49/0008 (2013.01); C07K 14/70596 (2013.01); C07K 16/2809 (2013.01); C07K 16/2887 (2013.01); C12N 9/16 (2013.01); C12N 15/8509 (2013.01); C12N 15/89 (2013.01); C12N 15/907 (2013.01); G01N 33/5011 (2013.01); G01N 33/5088 (2013.01); A01K 2207/12 (2013.01); A01K 2207/15 (2013.01); A01K 2217/05 (2013.01); A01K 2217/052 (2013.01); A01K 2217/054 (2013.01); A01K 2217/072 (2013.01); A01K 2227/10 (2013.01); A01K 2227/105 (2013.01); A01K 2267/01 (2013.01); A01K 2267/0331 (2013.01); A01K 2267/0381 (2013.01); A01K 2267/0387 (2013.01); C07K 14/70503 (2013.01); C07K 2317/31 (2013.01); C07K 2319/00 (2013.01); C12N 15/902 (2013.01); C12N 2015/8518 (2013.01); C12N 2015/8527 (2013.01); C12N 2015/8572 (2013.01); C12N 2800/30 (2013.01); C12Y 301/03048 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01);
Abstract

Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.

Find Patent Forward Citations

Murphy, Andrew. (2019). Non-human animals having a humanized signal-regulatory protein gene (U.S. Patent No. 10206379). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10206379

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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