The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2019
Filed:
Jun. 07, 2012
Applicant:
Wen Luo, San Diego, CA (US);
Inventor:
Wen Luo, San Diego, CA (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C40B 30/04 (2006.01); C12Q 1/6886 (2018.01); C07K 14/705 (2006.01); G06F 19/00 (2018.01); G16H 50/20 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C07K 14/70567 (2013.01); G06F 19/704 (2013.01); G16H 50/20 (2018.01); C12Q 2600/106 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/178 (2013.01); C40B 30/04 (2013.01); G01N 2500/00 (2013.01); G01N 2800/52 (2013.01);
Abstract
The present invention describes genomic biomarkers that have been discovered to correlate with varied individual responses (efficacy, adverse effect, and other end points) to therapeutic retinoid X receptor modulator, such as bexarotene, in treating diseases such as, non small cell lung cancer. The newly discovered biomarkers and others in linkage disequilibrium with them can be used in companion diagnostic tests which can help to predict drug responses and apply drugs only to those who will be benefited, or exclude those who might have adverse effects, by the treatment.