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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10202631 B1

PDFFull Text
Date of Patent:
Feb. 12, 2019

Filed:

Mar. 14, 2014

Multi-tiered, high through-put screen for compounds effective against bacterial biofilm compounds effective for inhibiting and eradicating bacterial biofilm

Applicants:

University of Cincinnati, Cincinnati, OH (US);

The United States of America, As Represented BY the Secretary of the Air Force, Washington, DC (US);

Inventors:

Daniel J. Hassett, Cincinnati, OH (US);

Thomas J. Lamkin, Cincinnati, OH (US);

Warunya Panmanee, Cincinnati, OH (US);

Deborah E. Taylor, Cincinnati, OH (US);

Chloe J. A. Shea, Cincinnati, OH (US);

Assignees:

University of Cincinnati, Cincinnati, OH (US);

The United States of America as Represented by the Secretary of the Air Force, Washington, DC (US);

Attorney:

Dinsmore & Shohl LLP

Primary Examiner:

Karla A Dines

Int. Cl.
CPC ...
C12Q 1/18 (2006.01); A61K 31/175 (2006.01); A61K 31/18 (2006.01); A61K 31/216 (2006.01); A61K 31/343 (2006.01); A61K 31/404 (2006.01); A61K 31/4155 (2006.01); A61K 31/4184 (2006.01); A61K 31/4245 (2006.01); A61K 31/425 (2006.01); A61K 31/435 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A01N 37/10 (2006.01); A01N 37/28 (2006.01); A01N 41/06 (2006.01); A01N 43/12 (2006.01); A01N 43/38 (2006.01); A01N 43/42 (2006.01); A01N 43/44 (2006.01); A01N 43/52 (2006.01); A01N 43/54 (2006.01); A01N 43/56 (2006.01); A01N 43/80 (2006.01); A01N 43/82 (2006.01); A01N 43/90 (2006.01); A01N 47/38 (2006.01); C07C 69/738 (2006.01); C07C 243/28 (2006.01); C07C 311/21 (2006.01); C07D 209/08 (2006.01); C07D 215/52 (2006.01); C07D 215/56 (2006.01); C07D 231/20 (2006.01); C07D 235/18 (2006.01); C07D 271/12 (2006.01); C07D 275/03 (2006.01); C07D 307/92 (2006.01); C07D 401/04 (2006.01); C07D 405/04 (2006.01); C07D 405/14 (2006.01); C07D 413/04 (2006.01); C07D 471/04 (2006.01); C07D 491/052 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/18 (2013.01); A01N 37/10 (2013.01); A01N 37/28 (2013.01); A01N 41/06 (2013.01); A01N 43/12 (2013.01); A01N 43/38 (2013.01); A01N 43/42 (2013.01); A01N 43/44 (2013.01); A01N 43/52 (2013.01); A01N 43/54 (2013.01); A01N 43/56 (2013.01); A01N 43/80 (2013.01); A01N 43/82 (2013.01); A01N 43/90 (2013.01); A01N 47/38 (2013.01); A61K 31/175 (2013.01); A61K 31/18 (2013.01); A61K 31/216 (2013.01); A61K 31/343 (2013.01); A61K 31/404 (2013.01); A61K 31/4155 (2013.01); A61K 31/4184 (2013.01); A61K 31/425 (2013.01); A61K 31/4245 (2013.01); A61K 31/435 (2013.01); A61K 31/4545 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); C07C 69/738 (2013.01); C07C 243/28 (2013.01); C07C 311/21 (2013.01); C07D 209/08 (2013.01); C07D 215/52 (2013.01); C07D 215/56 (2013.01); C07D 231/20 (2013.01); C07D 235/18 (2013.01); C07D 271/12 (2013.01); C07D 275/03 (2013.01); C07D 307/92 (2013.01); C07D 401/04 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 471/04 (2013.01); C07D 491/052 (2013.01);
Abstract

A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include as says for total bacterial growth, bacterial metabolic activity, and biofilm formation.

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