The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2019
Filed:
Dec. 07, 2015
Applicant:
Université Laval, Québec, (Québec), CA;
Inventors:
Assignee:
UNIVERSITÉ LAVAL, QUÉBEC, CA;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); A61K 48/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C07K 2317/24 (2013.01); C07K 2317/35 (2013.01); C07K 2317/52 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/82 (2013.01); C12N 2750/14143 (2013.01);
Abstract
Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of blocking the interaction of TDP-43 with NF-κB in cells. Also provided herein are method of using the antigen-binding constructs in the treatment of diseases associated with TPD-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS), frontotemperal lobar degeneration (FTLD), Lewy body disease and motor neuron disease.