The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2019
Filed:
Jun. 27, 2014
Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;
Universite DE Nantes, Nantes, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Universite D'angers, Angers, FR;
Yannick Jacques, Nantes, FR;
Erwan Mortier, Nantes, FR;
Agnes Quemener, Nantes, FR;
Ariane Plet, Nantes, FR;
INSERM (Institut National de la Sante et de la Recherche Medicale), Paris, FR;
Universite de Nantes, Nantes, FR;
Centre National de la Recherche Scientifique (CNRS), Paris, FR;
Universite D'Angers, Angers, FR;
Abstract
The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In particular, the present invention relates to an IL-15 mutant polypeptide having the amino acid sequence as set forth in SEQ ID NO:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagines residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue.