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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10202388 B1

PDFFull Text
Date of Patent:
Feb. 12, 2019

Filed:

Feb. 03, 2016

Fused-ring compounds, pharmaceutical composition and uses thereof

Applicant:

Shanghai DE Novo Pharmatech Co., Ltd., Shanghai, CN;

Inventors:

Qun Li, Shanghai, CN;

Daxin Gao, Shanghai, CN;

Assignee:

SHANGHAI DE NOVO PHARMATECH CO., LTD., Shanghai, CN;

Attorney:

Harness, Dickey & Pierce, P.L.C.

Primary Examiner:

Erich A Leeser

Int. Cl.
CPC ...
C07D 471/14 (2006.01); C07D 519/00 (2006.01); C07F 9/6561 (2006.01); A61K 45/06 (2006.01); A61K 31/4188 (2006.01); A61K 31/423 (2006.01); A61K 31/4245 (2006.01); A61K 31/428 (2006.01); A61K 31/437 (2006.01); A61K 31/439 (2006.01); A61K 31/4439 (2006.01); A61K 31/5377 (2006.01); A61K 31/635 (2006.01); A61K 31/675 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4188 (2013.01); A61K 31/423 (2013.01); A61K 31/428 (2013.01); A61K 31/4245 (2013.01); A61K 31/437 (2013.01); A61K 31/439 (2013.01); A61K 31/4439 (2013.01); A61K 31/5377 (2013.01); A61K 31/635 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07D 471/14 (2013.01); C07D 519/00 (2013.01); C07F 9/6561 (2013.01);
Abstract

This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.

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