The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 12, 2019

Filed:

Feb. 18, 2015
Applicant:

Glaxosmithkline Intellectual Property (No.2) Limited, Brentford, Middlesex, GB;

Inventors:

Keith Biggadike, Stevenage, GB;

Aurelie Cecile Champigny, Stevenage, GB;

Diane Mary Coe, Stevenage, GB;

Daniel Terence Tape, Stevenage, GB;

Stephen Allan Smith, Stevenage, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61K 39/39 (2006.01); A61P 37/08 (2006.01); A61P 11/06 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61P 25/00 (2006.01); A61P 31/00 (2006.01); A61P 43/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/519 (2013.01); A61K 39/39 (2013.01); A61K 2039/55511 (2013.01);
Abstract

Compounds of formula (I) and salts thereof: wherein Ris hydrogen, methyl or —(CH)OR, Ris methyl or —(CH)OR, or Rand R, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 6-membered heterocyclyl is optionally substituted by two hydroxy substituents; Rand Rare each independently hydrogen or methyl; and n is an integer having a value of 5 or 6, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment or prevention of various disorders, for example the treatment or prevention of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants.


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