The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 12, 2019

Filed:

Jun. 12, 2015
Applicants:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);

University of Kansas, Lawrence, KS (US);

Inventors:

Tsanyang Liang, Potomac, MD (US);

Zongyi Hu, Potomac, MD (US);

Juan Jose Marugan, Gaithersburg, MD (US);

Noel Terrence Southall, Potomac, MD (US);

Shanshan He, North Bethesda, MD (US);

Xin Hu, Frederick, MD (US);

Jingbo Xiao, Rockville, MD (US);

Marc Ferrer, Potomac, MD (US);

Wei Zheng, Potomac, MD (US);

Kevin J. Frankowski, Lawrence, KS (US);

Frank J. Schoenen, Lawrence, KS (US);

Kelin Li, Lawrence, KS (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/14 (2006.01); A61K 31/4545 (2006.01); C07D 417/14 (2006.01); C07D 471/08 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); C07D 413/06 (2006.01); A61K 31/4178 (2006.01); A61K 31/454 (2006.01); A61K 31/7056 (2006.01); A61K 31/7068 (2006.01); A61K 38/07 (2006.01); A61K 38/13 (2006.01); A61K 38/21 (2006.01);
U.S. Cl.
CPC ...
C07D 413/06 (2013.01); A61K 31/4178 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/7056 (2013.01); A61K 31/7068 (2013.01); A61K 38/07 (2013.01); A61K 38/13 (2013.01); A61K 38/212 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01); Y02A 50/385 (2018.01);
Abstract

Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.


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