The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2019
Filed:
Mar. 13, 2014
Applicant:
Tolero Pharmaceuticals, Inc., Lehi, UT (US);
Inventors:
Alexis Mollard, Salt Lake City, UT (US);
Steven L. Warner, Sandy, UT (US);
Gary A. Flynn, Oro Valley, AZ (US);
Hariprasad Vankayalapati, Draper, UT (US);
David J. Bearss, Alpine, UT (US);
Assignee:
Tolero Pharmaceuticals, Inc., Lehi, UT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/48 (2006.01); C07D 401/14 (2006.01); C07D 401/12 (2006.01); A61K 31/44 (2006.01); A61K 31/496 (2006.01); A61K 31/505 (2006.01);
U.S. Cl.
CPC ...
C07D 239/48 (2013.01); A61K 31/44 (2013.01); A61K 31/496 (2013.01); A61K 31/505 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01);
Abstract
Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R, R, R, R, R, R, R, X, z and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.