The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 12, 2019

Filed:

Mar. 13, 2013
Applicant:

Tepha, Inc., Lexington, MA (US);

Inventors:

David P. Martin, Arlington, MA (US);

Kai Guo, Waltham, MA (US);

Said Rizk, Windham, NH (US);

Simon F. Williams, Sherborn, MA (US);

Assignee:

Tepha, Inc., Lexington, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 31/14 (2006.01); A61F 2/00 (2006.01); A61L 17/14 (2006.01); A61L 17/10 (2006.01); A61L 15/42 (2006.01); A61L 27/34 (2006.01); A61L 31/10 (2006.01); A61L 27/56 (2006.01); A61L 15/26 (2006.01); D01F 6/62 (2006.01); C08L 67/04 (2006.01); D01D 5/00 (2006.01); A61L 27/18 (2006.01); A61L 2/28 (2006.01); A61F 2/28 (2006.01);
U.S. Cl.
CPC ...
A61L 31/14 (2013.01); A61F 2/00 (2013.01); A61F 2/28 (2013.01); A61L 15/26 (2013.01); A61L 15/425 (2013.01); A61L 17/105 (2013.01); A61L 17/145 (2013.01); A61L 27/34 (2013.01); A61L 27/56 (2013.01); A61L 31/10 (2013.01); A61L 31/146 (2013.01); D01D 5/0038 (2013.01); D01F 6/625 (2013.01); A61L 2400/12 (2013.01); Y10T 428/249953 (2015.04); Y10T 428/298 (2015.01); Y10T 442/10 (2015.04); Y10T 442/681 (2015.04);
Abstract

Methods to produce structures containing ultrafine fibers with average diameters from 10 nm to 10 μm and more preferably from 50 nm to 5 μm, have been developed. These methods produce ultrafine fibers without substantial loss of the polymer's weight average molecular weight. The ultrafine electrospun fibers have an unexpectedly higher degree of molecular orientation, and higher melt temperature than fibers derived by dry spinning. In the preferred embodiment, the polymer comprises 4-hydroxybutyrate. The ultrafine fibers are preferably derived by electrospinning. A solution of the polymer is dissolved in a solvent, pumped through a spinneret, subjected to an electric field, and ultrafine fibers with a high degree of molecular orientation are collected. These structures of ultrafine fibers can be used for a variety of purposes including fabrication of medical devices.


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