logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10201614 B1

PDFFull Text
Date of Patent:
Feb. 12, 2019

Filed:

Mar. 14, 2014

Cytotoxic and anti-mitotic compounds, and methods of using the same

Applicant:

Zymeworks Inc., Vancouver, CA;

Inventors:

Geoffrey C. Winters, Vancouver, CA;

Alexander Laurence Mandel, Vancouver, CA;

James R. Rich, Vancouver, CA;

Bradley John Hedberg, Vancouver, CA;

Tom Han Hsiao Hsieh, Vancouver, CA;

Elyse Marie Josée Bourque, Blaine, WA (US);

John Babcook, Vancouver, CA;

Assignee:

ZYMEWORKS INC., Vancouver, British Columbia, unknown;

Attorneys:

Todd A. Lorenz

David Goetz

Primary Examiner:

Sun Jae Yoo

Int. Cl.
CPC ...
C07D 211/60 (2006.01); C07D 211/34 (2006.01); C07D 213/56 (2006.01); C07D 213/71 (2006.01); C07D 333/34 (2006.01); A61K 38/06 (2006.01); A61K 31/445 (2006.01); A61K 38/05 (2006.01); C07C 311/51 (2006.01); C07C 323/12 (2006.01); C07C 323/67 (2006.01); A61K 47/48 (2006.01); A61K 39/395 (2006.01); C07C 327/06 (2006.01); C07C 381/08 (2006.01); C07D 207/08 (2006.01); C07D 207/452 (2006.01); C07K 5/02 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48415 (2013.01); A61K 31/445 (2013.01); A61K 38/05 (2013.01); A61K 38/06 (2013.01); A61K 39/3955 (2013.01); A61K 47/48261 (2013.01); C07C 311/51 (2013.01); C07C 323/12 (2013.01); C07C 323/67 (2013.01); C07C 327/06 (2013.01); C07C 381/08 (2013.01); C07D 207/08 (2013.01); C07D 207/452 (2013.01); C07D 211/34 (2013.01); C07D 211/60 (2013.01); C07D 213/56 (2013.01); C07D 213/71 (2013.01); C07D 333/34 (2013.01); C07K 5/0205 (2013.01); C07C 2101/02 (2013.01); C07C 2101/08 (2013.01); C07C 2101/14 (2013.01);
Abstract

Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.

Find Patent Forward Citations

Loading…