The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 12, 2019

Filed:

Nov. 07, 2016
Applicants:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Warren Jaye Leonard, Bethesda, MD (US);

Erin Elizabeth West, Washington Grove, MD (US);

Rosanne Spolski, Silver Spring, MD (US);

K. Christopher Garcia, Menlo Park, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/04 (2006.01); A61K 38/16 (2006.01); A61K 38/19 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/19 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01);
Abstract

The invention provides a method of promoting the host defense of a patient to a bacterial infection comprising administering to a patient suffering or at risk of a bacterial infection, a pharmaceutical composition comprising an effective amount of the pleiotropic cytokine, thymic stromal lymphopoietin (TSLP) protein or polypeptide in an amount and at a location sufficient to promote the host defense of the patient to the bacterial infection. In a preferred embodiment, the bacterial infection is the infection of the patient with MRSA. The invention also provides a method of treating blood product, which comprises introducing a TSLP protein or polypeptide into such blood product, wherein the blood product is extracorporeal and comprises at least one neutrophil.


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