The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2019
Filed:
Sep. 05, 2014
Applicant:
Howard University, Washington, DC (US);
Inventor:
Pradeep K. Karla, Washington, DC (US);
Assignee:
Howard University, , DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/675 (2006.01); A61K 9/06 (2006.01); A61K 31/47 (2006.01); A61K 45/06 (2006.01); A61K 31/4745 (2006.01); A61K 31/4985 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/675 (2013.01); A61K 9/0034 (2013.01); A61K 9/06 (2013.01); A61K 31/47 (2013.01); A61K 31/4745 (2013.01); A61K 31/4985 (2013.01); A61K 45/06 (2013.01);
Abstract
Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).