The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2019
Filed:
Sep. 07, 2017
Thermo Fisher Scientific (Bremen) Gmbh, Brenmen, DE;
California Institute of Technology, Pasadena, CA (US);
John Eiler, Sierra Madre, CA (US);
Jens Griep-Raming, Ganderkesee, DE;
Alexander Makarov, Bremen, DE;
Johannes Schwieters, Ganderkesee, DE;
Dieter Juchelka, Bremen, DE;
California Institute of Technology, Pasadena, CA (US);
Thermo Fisher Scientific (Bremen) GmbH, Bremen, DE;
Abstract
The present inventive concepts relate to determining an isotope ratio using mass spectrometry. Mass spectra of ions are obtained by generating ions, guiding the ions through a device having a mass transfer function that varies with ion current, providing at least some of the ions to a mass analyzer and obtaining a mass spectrum of the ions and determining the ion current of the ions provided to the mass analyzer. An isotope ratio of the ions is determined for each mass spectrum. Using the determined isotope ratio and determined ion current for each mass spectrum, a calibration relationship is determined that characterizes the variation of the determined isotope ratios and the measured ion currents across the mass spectra. Then, a measured isotope ratio obtained at a determined ion current is adjusted using the calibration relationship to adjust the measured isotope ratio to an adjusted isotope ratio corresponding to a selected ion current.