The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2019
Filed:
Dec. 19, 2014
Wan Y. Shih, Bryn Mawr, PA (US);
Wei Wu, Philadelphia, PA (US);
Wei-heng Shih, Bryn Mawr, PA (US);
Mehmet Cagri Soylu, Melikgazi (Kayseri), TR;
Haitao Guo, Carmel, IN (US);
Suresh G. Joshi, Secane, PA (US);
Ceyhun Ekrim Kirimli, Thunder Bay, CA;
Ying-hsiu Su, Audubon, PA (US);
Wan Y. Shih, Bryn Mawr, PA (US);
Wei Wu, Philadelphia, PA (US);
Wei-Heng Shih, Bryn Mawr, PA (US);
Mehmet Cagri Soylu, Melikgazi (Kayseri), TR;
Haitao Guo, Carmel, IN (US);
Suresh G. Joshi, Secane, PA (US);
Ceyhun Ekrim Kirimli, Thunder Bay, CA;
Ying-Hsiu Su, Audubon, PA (US);
DREXEL UNIVERSITY, Philadelphia, PA (US);
Abstract
A piezoelectric plate sensor comprising a piezoelectric layer; two electrodes; and an insulation layer. The insulation layer is produced by soaking the piezoelectric layer and two electrodes in a mercaptopropyltrimethoxysilane solution with an amount of water from 0.1 v/v. % to about 1 v/v % and at pH from about 8 to about 150 for a period from about 8 to about 15 hours, and the mercaptopropyltrimethoxysilane solution has a concentration of mercaptopropyltrimethoxysilane from about 0.01 v/v % to about 0.5 v/v %. A method of detecting a biomolecule in a sample using the piezoelectric plate sensor in particular, that of detecting a genetic marker with PCR sensitivity and specificity without the need of DNA isolation or amplification is also provided. The piezoelectric plate sensor may be used to diagnose various diseases including breast cancer, myocardial infarction, diarrhea,infection, and hepatitis B infection.