The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2019
Filed:
Dec. 28, 2015
Oakland University, Rochester, MI (US);
Xiangqun Zeng, Rochester Hills, MI (US);
Gerard Madlambayan, Rochester, MI (US);
Liang Tan, Changsha, CN;
Bahareh Pezeshkian, Rochester, MI (US);
Abdul Rehman, Dhahran, SA;
Oakland University, Rochester, MI (US);
Abstract
In a method for monitoring cell-to-cell interactions, a quartz crystal microbalance surface is exposed to a medium including a first cell. The first cell is exposed to a sample including a suspect cell. The first cell is activated prior to or simultaneously with the first cell exposure. Frequency and motional resistance changes versus time are measured after each of: surface exposure to the medium, first cell activation prior to the exposure to the sample, and first cell exposure to the sample; or after each of: surface exposure to the medium and simultaneous first cell activation and sample exposure. From the frequency and motional resistance changes versus time, any of i) a level of adhesion of the suspect cell to the activated first cell, ii) a type of the suspect cell, iii) a behavior or activity of the suspect cell is determined, or iv) activation of the first cell is determined.